Post-doc available

The Hawkins group has a BBSRC funded post-doc available for 2023-6.

We are looking for a highly motivated Research Associate to work on a BBSRC-funded project aimed at characterising collisions of the bacterial replication machinery with protein obstacles. This project will exploit the biochemical tractability of Escherichia coli to investigate fundamental aspects of DNA replication at the DNA, protein and complex/super-complex level. The project will focus on studying the mechanistic consequences of replication obstacles for replisomes, resolution of replisome collisions by helicases, and understanding the impact of replication-transcription conflicts on genome duplication. Developing a full molecular understanding of replisome-obstacle collisions is currently a major challenge in the field because they can impede replication fork progression and cause genome instability.

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